TABLE OF CONTENTS

VOLUME IVOLUME I – Diagnosis
Foreword: A European touch 
Valentin Fuster
Introduction: Bringing it all together, the Genesis of the PCR EAPCI textbook 
Eric Eeckhout, Patrick W. Serruys, William Wijns, Alec Vahanian, Marc van Sambeek, Rodney de Palma
Part I – Foundations of interventional cardiovascular medicine
A history of cardiac catheterisation 
Michel E. Bertrand, Bernhard Meier
A history of percutaneous coronary intervention 
Michel E. Bertrand, Bernhard Meier
Fluoroscopic anatomy for the guidance of percutaneous transcatheter interventions New chapter
Jeremy Ben-Shoshan1,2, Nicolo Piazza1, Pascal Thériault-Lauzier1, Michele Pighi1,3
Vascular access 
Olivier Bertrand, Rodney de Palma, David Meerkin
Vascular closure Video content
Rajiv Rampat, Anouska M. Moynagh, Marie-Claude Morice
Cardiac transseptal catheterisation 
Gregory Ducrocq, Thomas R.D. Shaw, Habib Gamra, Peter C. Block, Neil R. Grubb, Carlos E. Ruiz, Alec Vahanian
Endomyocardial biopsy Video content Updated chapter
Ali Yilmaz1, Karin Klingel2, Udo Sechtem3
Pericardiocentesis Video content
Richard Armstrong1, John D. Groarke2, Igor F. Palacios3, Andrew O. Maree1
Percutaneous ventricular assistance 
Juan N. Pulido, Saraschandra Vallabhajosyula, Charanjit S. Rihal
Radiation protection 
Eugenio Picano, Maria Grazia Andreassi, Madan M. Rehani, Leonardo Bolognese, Eliseo Vano
Contrast agents and renal protection 
Antonio L. Bartorelli, Giancarlo Marenzi
Sedation, pain management and resuscitation 
Astrid van Nieuwkerk, Ronak Delewi
Biostatistics for the interventionistUpdated chapter
Tim Collier1, Stuart Pocock1
Part II – Diagnostic cardiovascular modalities and their application
Cardiac biomarkers Addendum
Evangelos Giannitsis1, Christian Hamm, Holger Nef, Hugo A. Katus1
Fundamentals of coronary biomechanics 
Frank Gijsen, Peter Mortier, Matthieu De Beule, Jolanda Wentzel, Patrick Segers
Non-invasive imaging for coronary disease Video content
Juhani Knuuti, Philipp Kaufmann, Antti Saraste
Non-invasive imaging for structural heart disease Video content Updated chapter
Osama Soliman, 1, 2; Hesham Elzomor1, 2, 3, Victoria Delgado4, Nina Ajmone Marsan, Maarten Witsenburg, Carl Schultz, Martin J. Schalij, Jeroen J. Bax
Invasive diagnostic coronary angiography Video content
Guy R. Heyndrickx, Aaron J. Peace, Chrysafios Girasis, Christoph K. Naber, Christos V. Bourantas, Patrick W. Serruys
Invasive haemodynamic assessment 
Mohamed A. Omer, Paul Sorajja, Rick A. Nishimura
Invasive physiological assessment of coronary disease (FFR) 
Pim A.L. Tonino, Daniëlle C.J. Keulards, Nico H.J. Pijls
Invasive physiological assessment of coronary disease: non-hyperaemic indices (iFR) Updated chapter
Nieves Gonzalo1, Hernán Mejía-Rentería1, Angela McInerney1, Javier Escaned1
Computational non-invasive physiological assessment of coronary disease Updated chapter
Julien Adjedj1, Jelmer Westra2, Daixin Ding3, 4, Junqing Yang5, William Wijns4, Shengxian Tu3
Assessment of coronary vasoreactivity and the microcirculation 
Thomas F Lüscher1, 2, Andreas F. Flammer3, Amir Lerman4, Michel T. Corban4
Intracardiac echocardiography Video content
Anna E. Bortnick, Rim Halaby, Frank E. Silvestry, Howard C. Herrmann
Intravascular ultrasound 
Hector M. García-García, Fernando Alfonso
Optical coherence tomography Video content Updated chapter
Francesco Prati1,2,3, Alessandro Sticchi1,2, Evelyn Regar4
Near-infrared spectroscopy Addendum
James A. Goldstein, Salvatore Brugaletta, Sean P. Madden, Stephen T. Sum, Simon R. Dixon, Ryan D. Madder, Patrick W. Serruys, James E. Muller
VOLUME IIVOLUME II – Intervention I
Part III – Percutaneous interventions for cardiovascular disease
Guide catheters and wires Video content
Soo Teik Lim, Tian Hai Koh
Balloon angioplasty technology 
Tassilo Bonzel, Christian Hamm, Volker Schächinger, Gerhard Strupp, Boris Lescot, Didier Tchetche
Coronary artery stents 
Scot Garg, Sharmaine Thirunavukarasu, Raffaele Piccolo, Patrick W Serruys, Stephan Windecker
Bioresorbable scaffolds 
Yoshinobu Onuma, Yuki Katagiri, Athanasios Katsikis, Antoine Lafont, Alexander Abizaid, Ron Waksman, John Ormiston, Patrick W. Serruys
Drug-coated balloons Updated chapter
Bruno Scheller1
Calcified coronary lesionsVideo content Updated chapter
Farrel Hellig1, 2, Pieter Van Wyk1, Emanuele Barbato, Shaheen Pandie3, 4
Directional atherectomy 
Antonio Colombo, Azeem Latib
Laser therapy 
Michael Haude, Miltos Papalexandris, Hubertus Degen
Distal protection and thrombectomyUpdated chapter
Angelo Quagliana1, Simone Biscaglia2, Anna Giulia Pavon1, Marco Valgimigli1
Bifurcation lesions 
Thierry Lefèvre, Thomas Hovasse
Ostial lesions 
Christoph K. Naber, Thomas Schmitz, Eberhard Grube, Georg V. Sabin
Left main coronary artery disease 
Rodrigo Modolo1,2, Norihiro Kogame1, Hidenori Komiyama1, Vasim Farooq, Gregg Stone, Renu Virmani, Patrick W. Serruys
Chronic total occlusions Updated chapter
Gerald S. Werner1
The hybrid approach to CTO intervention Video content New chapter
Emmanouil S. Brilakis 1, Lorenzo Azzalini 2, Dimitri Karmpaliotis 3, William Nicholson4, Stephane Rinfret 5
Saphenous vein graft disease 
Gabriel Maluenda1, Itsik Ben-Dor2, Augusto D. Pichard2
Spontaneous coronary artery dissections Video content New chapter
David Adlam1, Fernando Alfonso2, Angela Maas3, Alexandre Persu4, Christiaan Vrints5
Risk stratification and risk models in revascularisation Updated chapter
Hironori Hara1, 2, Kuniaki Takahashi1, Vasim Farooq3, David R Holmes4, Yoshinobu Onuma2, Patrick W. Serruys2
Interventions for stable coronary disease (chronic coronary syndromes) Addendum
Pradyumna E. Tummala, Bill D. Gogas, Robert Guyton, David O. Williams, Spencer B. King III
Interventions for ST-segment elevation acute myocardial infarction 
Dariusz Dudek, Carlo Di Mario, Giuseppe De Luca, Artur Dziewierz, Tomasz Rakowski
Interventions for non-ST-segment elevation acute coronary syndromes 
Helge Möllmann1, Holger M. Nef2, Johannes Blumenstein1, Christian W. Hamm2,3
Ischemia and myocardial infarction without obstructive coronary artery disease New chapter
Alaide Chieffo1, Valeria Paradies2, Alessandro Beneduce1, Javier Escaned3
Lesion and patient subsets: chronic kidney disease 
Roberto Scarsini1, Michele Pighi1, Gabriele Venturi1, Flavio Ribichini1
Secondary coronary revascularisation 
Breda Hennessey, Hernán Mejía-Rentería, Nieves Gonzalo, Javier Escaned
Hybrid interventions 
Oana Bodea, Frank Van Praet, Hugo Vanermen, Philippe Kolh, Bernard De Bruyne
The interventional management of out-of-hospital cardiac arrest Video content Updated chapter
Marko Noc1, Peter Radsel2, Emmanouil Poulidakis3, Christian Spaulding4
Cardiogenic shock Updated chapter
Holger Thiele, Pascal Vranckx, Gerhard Schuler
The prevention and management of complications during percutaneous coronary intervention 
Rodney De Palma, Christian Roguelov, Adel Aminian, Olivier Muller, Tito Kabir, Eric Eeckhout
Stent thrombosis 
Dean J. Kereiakes, Ian J. Sarembock
In-stent restenosis 
Vasim Farooq, Lorenz Räber, Bill D. Gogas, Patrick W. Serruys
The high bleeding risk patient Updated chapter
Róisín Colleran1,2, Philip Urban3,4
Secondary prevention of atherosclerotic cardiovascular disease Updated chapter
Guy De Backer1, Paul Dendale2, Christiaan Vrints3
VOLUME IIIVOLUME III – Intervention II
Part III – Percutaneous interventions for cardiovascular disease
Percutaneous balloon mitral commissurotomy  
Alec Vahanian, Dominique Himbert, Eric Brochet, Gregori Ducrocq, Marina Urena, Bernard Iung
Transcatheter mitral valve repair Updated chapter
Olaf Franzen1, Maurizio Taramasso2, Matjaz Bunc3, Lars Søndergaard4, Ole De Backer4
Transcatheter mitral valve implantation Updated chapter
Maurizio Taramasso1, Giulio Russo1, 2, Andrea Guidotti, Neil Moat, Anson Cheung, Dominique Himbert, Alison Duncan, Alasdair J. Watson, Nico Piazza, Francesco Maisano1
Transcatheter tricuspid valve interventions Updated chapter
Jean-Michel Juliard, Giulio Russo1, 2, Alec Vahanian, Azeem Latib, Eric Brochet, Phalla Ou, Dominique Himbert, Maurizio Taramasso1, Francesco Maisano1
Balloon aortic valvuloplasty Video content
Eric Durand, John Webb, Hélène Eltchaninoff
Transcatheter aortic valve implantation Updated chapter New chapter Addendum
Taishi Okuno1, Daijiro Tomii1, Thomas Pilgrim1, Stephan Windecker1
Percutaneous management of valve bioprothesis dysfunction New chapter
Danny Dvir
Percutaneous pulmonary valvuloplasty Video content
Louise Coats, Philipp Lurz, Ingo Daehnert, Philipp Bonhoeffer
Percutaneous pulmonary valve implantation 
Robert Wagner, Ingo Daehnert, Philipp Bonhoeffer, Philipp C. Lurz
Atrial septal defect and patent foramen ovale closure Video content
Jochen Wöhrle1, Julia Seeger1
Ventricular septal defect closure Video content
Gianfranco Butera1,2 , Mario Giordano3 , Quang N. Nguyen4 , Biagio Castaldi5 , Luciane Piazza6, Massimo Chessa6, Mario Carminati6
Patent ductus arteriosus closure 
Massimo Chessa1, Angelo Fabio D'Aiello1, Diana Gabriela Negura1, Biagio Castaldi2, Gianfranco Butera3, Mario Carminati1
Left atrial appendage occlusion 
Daniel H. Steinberg, Stefan Bertog, Jennifer Franke, Jens Wiebe, Nina Wunderlich, Horst Sievert
Coarctation of the aorta 
Tomohito Kogure1,2, Benjamin G. Smith3, Shakeel A. Qureshi1
Percutaneous closure of paravalvular leaks Video content
Yuriy Dudiy, Tilak K. R. Pasala, Carlos E. Ruiz
Carotid artery stenting 
Alberto Cremonesi, Marco Roffi, Estevao Carvalho De Campos Martins, Fausto Castriota
Subclavian, brachiocephalic and vertebral interventions 
Alberto Cremonesi, Marco Roffi, Estevao Carvalho De Campos Martins, Fausto Castriota, Roberto Nerla
Thoracic and abdominal aortic disease 
Christoph A. Nienaber, Edith M. Willigendael, Ibrahim Akin, Stephan Kische, Marc R.H.M. Van Sambeek
Peripheral arterial occlusive disease Updated chapter
Alberto Cremonesi1, Roberto Nerla2, Nicolas Diehm3, Andrej Schmidt4, Dierk Scheinert4, Iris Baumgartner3, Antonio Micari5, Fausto Castriota2
Interventions for varicose veinsUpdated chapter
Eveline Scheerders1, Renate R. Van Den Bos1
Closure of arteriovenous fistulae and malformations 
Stefan C. Bertog, Daniel H. Steinberg, Jennifer Franke, Nina Wunderlich, Horst Sievert, Peter N. Ruygrok
Alcohol septal ablation for hypertrophic obstructive cardiomyopathy 
Hubert Seggewiss, Angelika Batzner, Angelos G. Rigopoulos
Alternative techniques to alcohol septal ablation for hypertrophic obstructive cardiomyopathy 
Marco G. Mennuni1, Nicole Karam2, Eric Durand3, Bachir Allam4, Antoine Lafont2
Concept, techniques and clinical effectiveness of renal nerve ablation in hypertension 
Andrea Denegri, Isabella Sudano, Christian Templin, Ulf Landmesser, Felix Mahfoud, Thomas F. Lüscher
Techniques of myocardial stem cell delivery Video content
Jozef Bartunek, Anthony Mathur, Marc Vanderheyden
Cell-based regenerative therapy Updated chapter
Anthony Mathur 1, 2, Alice Reid1
Pulmonary embolism and pulmonary hypertension 
Klaus Distelmaier, Irene M. Lang
Balloon pulmonary angioplasty 
Hiroto Shimokawahara, Aiko Ogawa, Hiromi Matsubara
Endovascular treatment of acute ischemic stroke 
Maxim Mokin, Jason M. Davies, Kenneth V. Snyder, Adnan H. Siddiqui, Elad I. Levy, L. Nelson Hopkins
VOLUME IVVOLUME IV – Perspectives
Part IV – Interventional cardiovascular medicine into context
The Heart team 
Stuart J. Head, Nicolas M. Van Mieghem, Patrick W. Serruys, Arie Pieter Kappetein
Ethics in cardiovascular interventions 
Peter Lanzer1, Chrystian Rybak2, Michael Norell3
The cardiac catheterisation laboratory environment 
Jacques J. Koolen, Rodney De Palma, Lukas Dekker
Administration and data collection Updated chapter
Suleman Aktaa1, Andreas Baumbach2, Peter F Ludman3
Clinical trial design 
Pallav Garg, Adnan Kastrati, Laura Mauri
Quality of life assessment 
Mattie Lenzen, Ron Van Domburg, Susanne S. Pedersen
Risk-benefit analysis Updated chapter
Salvatore Brugaletta1, Patrick W. Serruys2, Vasim Farooq3, Victor Arevalos1, Sally C. Stearns
Cost and cost-effectiveness 
Isabelle Durand-Zaleski
Interventional cardiology training 
Carlo Di Mario, Michael Haude, Martine Gilard, Lino Goncalves, Ulf Jensen
Consensus on definitions of clinical endpoints: percutaneous coronary and valvular intervention trials Updated chapter
Pascal Vranckx1, Donald E. Cutlip, Roxana Mehran2, Martin B. Leon3, Patrick W. Serruys4
Large animal models for the interventional cardiologist: a comparative anatomy, imaging, histopathology and regulatory perspective Video content New chapter
Nicolas Borenstein, Luc Behr, Alexis Morlet, Olivier Chevènement, Robert Kieval, Angélique Ente, Laurence Fiette
Robots in interventional cardiology New chapter
Paul Jau Lueng Ong1, 2, Fahim Haider Jafary2, Deborah JinHyun Lee2
The COVID Pandemic and Interventional Practice New chapter
Jose David Tafur1, Christopher J White2
Part V – Annexes
Interventional pharmacology 
Sotiris Antoniou, Paul Wright, Rodney de Palma
Interventional innovation landscape 
Hollis Call, Eric Lehto, Paul Cummins, Patrick W. Serruys